منابع مشابه
Effect of Cannabinoid Receptor Activation on Spreading Depression
Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...
متن کاملActivation of postnatal neural stem cells requires nuclear receptor TLX.
Neural stem cells (NSCs) continually produce new neurons in postnatal brains. However, the majority of these cells stay in a nondividing, inactive state. The molecular mechanism that is required for these cells to enter proliferation still remains largely unknown. Here, we show that nuclear receptor TLX (NR2E1) controls the activation status of postnatal NSCs in mice. Lineage tracing indicates ...
متن کاملEndothelial nuclear lamina is not required for glucocorticoid receptor nuclear import but does affect receptor-mediated transcription activation.
The lamina serves to maintain the nuclear structure and stiffness while acting as a scaffold for heterochromatin and many transcriptional proteins. Its role in endothelial mechanotransduction, specifically how nuclear mechanics impact gene regulation under shear stress, is not fully understood. In this study, we successfully silenced lamin A/C in bovine aortic endothelial cells to determine its...
متن کاملDirect activation: a concept to encourage tailoring activities
Volker Wulf and Björn Golombek ProSEC – Department for Computer Science III University of Bonn Römerstr. 164, 53111 Bonn Germany Tel: 1-301-403-4333 E-mail: {volker, bg}@informatik.uni-bonn.de ABSTRACT The design of the user interface plays a major role in encouraging users to tailor an application. In this paper, we focus on a particular design issue. The question is how to support users in fi...
متن کاملNuclear Receptor Signaling Atlas (): hyperlinking the nuclear receptor signaling community
The nuclear receptor signaling (NRS) field has generated a substantial body of information on nuclear receptors, their ligands and coregulators, with the ultimate goal of constructing coherent models of the biological and clinical significance of these molecules. As a component of the Nuclear Receptor Signaling Atlas (NURSA)--the development of a functional atlas of nuclear receptor biology--th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2009
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd2807